The Allen Mouse Brain Atlas is a three-dimensional atlas of gene expression throughout the adult mouse brain. The atlas is separated into four key features:In Situ Hybridization (ISH) Data includes image data with cellular level resolution. To find gene expression data, search can be performed using Gene Search, Differential Search, Fine Structure Search, Bulk Search, and Human Differential Search.Reference...

This study created an experimental model to assess the effects of early-life exposures to antibiotics on the intestinal microbiota and gene expression in the brain. For this study, C57BL/6 mice were breed for 5 days and the pregnant dams were randomized into 3 treatment groups. First group was treated with low-dose penicillin G in their drinking water starting during the last week of pregnancy and...

Choline is a vital nutrient that is used by the body to produce acetylcholine, which is an important neurotransmitter essential for brain and nervous system functions. Therefore, sufficient intake of dietary choline is important for proper brain function and neurodevelopment. It is especially critical for brain development during the perinatal period. This study investigated the impact of perinatal...

This study profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from participants in the Rush Religious Orders Study (RROS). The RROS participants included older religious clergy who have agreed to medical and psychological evaluation each year and brain donation after death. This study began in 1993 and has enrolled...

This study investigated whether the Alzheimer’s disease (AD) pathological lesions diffuse plaques (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs). For this study, downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia. They performed negative binomial (NB) regressions using gene expression...

Patients with Alzheimer’s disease (AD) have altered intestinal microbiota. Studies have shown that reduced intestinal microbiota in AD animal models decreases amyloid-beta (Aβ) plaque deposition. This age-related changes in the microbiota contribute to immunologic and physiologic decline. Previous study indicated that calorie restriction (CR) reduced brain Aβ deposition in Tg2576 mouse model of AD....

Dinucleoside tetraphosphates have been shown to function in bacteria as precursors to nucleoside tetraphosphate (Np4) RNA caps. The removal of this cap is critical for initiating 5′ end-dependent degradation of those RNAs, which affects bacterial adaptability to stress. This study described that the RNA pyrophosphohydrolase (RppH) assumes a leading role in decapping those transcripts in Escherichia...

This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes primary RNA sequencing data and other primary data, as well as supplementary data tied to the publication. The supplementary data contains tables, which...

This study performed loss-of-function screens in a transformed breast cell line using a metabolism-restricted short hairpin RNA (shRNA) library to understand differences in metabolic pathway requirements between in vitro model systems and in vivo tumors. They found that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. This dataset includes supplementary data tied...

MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...